Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians
نویسندگان
چکیده
منابع مشابه
Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians.
Although aflatoxins (AFs) have been shown to be immune-suppressive agents in animals, the potential role of AFs in modifying the distribution and function of leukocyte subsets in humans has never been assessed. We examined the cellular immune status of 64 Ghanaians in relation to levels of aflatoxin B1 (AFB1)-albumin adducts in plasma. The percentages of leukocyte immunophenotypes in peripheral...
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Title: Association Between Aflatoxin B1 Albumin Adduct Levels and Tuberculosis Infection Among HIV+ Ghanaians. Background: Aflatoxin exposure has been shown to cause cell-mediated immune suppression and enhance HIV viral replication. Such immune suppression from aflatoxin can impair resistance to both infectious diseases and chronic infections. Methods: Hazard ratios (HRs) with 95% confidence i...
متن کاملShort Communication Association of Aflatoxin B1-Albumin Adduct Levels with Hepatitis B Surface Antigen Status among Adolescents in Taiwan
Chronic hepatitis B virus (HBV) infection and aflatoxin B1 (AFB1) exposure interact synergetically to induce hepatocellular carcinoma. One suggested mechanism for this interaction is the enhanced activation of AFB1 in chronically HBV-infected individuals. Whereas no associations between chronic HBV infection and AFB1albumin adducts were observed in several studies in adults, hepatitis B surface...
متن کاملEnzyme immunoassay for aflatoxin B1-lysine adduct and its validation.
A simple procedure was developed for in vitro synthesis and characterization of aflatoxin B1-lysine adduct using aflatoxin B1, N-alpha-acetyl lysine and m-chloroperbenzoic acid (MCPBA). At a molar ratio of 1:16 (aflatoxin B1:N-alpha-cetyl lysine), the recovery of adduct was 62%. Analysis of the adduct by thin-layer chromatography showed a single spot (Rf = 0). Absorption spectra of the adduct s...
متن کاملSocio-demographic determinants of aflatoxin B1-lysine adduct levels among pregnant women in Kumasi, Ghana.
OBJECTIVES Aflatoxins are fungal metabolites that contaminate staple food crops in many developing countries. Although studies have linked these toxins to adverse birth outcomes and poor infant development, no study has investigated the socio-demographic and economic determinants of aflatoxin levels among pregnant women living in sub-Saharan Africa. DESIGN A cross-sectional study was conducte...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2005
ISSN: 1460-2377,0953-8178
DOI: 10.1093/intimm/dxh262